Natalie Karagodsky
Assistant Professor of Biology
Office Hours
Office: Wilkens Science Center, Room 309-G
Education
Sci.B., Brown University; Ph.D. Harvard University
As scientists in the making, college is a time to develop one's ability to think critically about problems, develop hypotheses, test these hypotheses with experiments, gather and analyze data, and effectively communicate the process and conclusions to others. This is not an easy feat. And is learned in stages. My goal is to try to make each stage of this process as engaging and relevant for students, as possible.
Complete understanding of new facts is often blocked by misconceptions. I try to identify and challenge students' misconceptions, while maintaining a positive and supportive classroom environment. This helps students develop metacognition-awareness of what they do and do not know, allowing them to self-monitor their understanding, to ask the right questions and eventually to advance their understanding, by fully integrating new information into their preexisting frameworks.
What I Love About Emmanuel:
I love the small classes, where students interact directly with faculty. I love the community, where faculty and staff are passionate and eager to help students succeed. I love the research environment, where students and faculty have the support and collaboration of one another, but also the opportunity to work with world renowned scientists at neighboring institutions. And I love the mission, where students and faculty are committed to service and social justice on campus and beyond.
Course I Teach
- BIOL 1106 Introduction to Organismic and Evolutionary Biology lab
- BIOL 2135 Anatomy and Physiology I lecture and lab
- BIOL 2137 Anatomy and Physiology II lecture and lab
Recent Publications
- Moroz N, C.J.J., A.E., Hart A, Sinclair DA, and Blackwell TK. Dietary Restriction Involves NAD+-dependent Mechanisms and a Shift Toward Oxidative Metabolism. Aging Cell, 2014. doi: 10.1111/acel.12273.
- M.M., N.H.E., Moroz N, L.Y. and Blackwell TK. mTORC2-SGK-1 Acts in Two Environmentally -responsive Pathways with Opposing Effects on Longevity. Aging Cell, 2014. doi: 10.1111/acel.12248.
- Moroz N, T.M., L.L., X.H., and de la Monte S. Limited Alzheimer-type Neurodegeneration in Experimental Obesity and Type 2 Diabetes Mellitus. J Alzheimers Dis, 2008. 15(1): p. 29-44.
My research interests focus on SKN-1/NF-E2 related factor, a conserved transcription factor that regulates redox regulators, such as glutathione S-transferase and thioredoxin, in the model organism Caenorhabditis elegans (C. elegans), a millimeter long worm. SKN-1 counters damage caused by reactive oxygen species, which is often implicated in age-associated diseases including diabetes, atherosclerosis, and neurodegenerative diseases. Recently, SKN-1 was shown to mediate fat accumulation and oxidative stress resistance in worms missing germline stem cells. The mechanism by which this occurs is unknown, and encompasses an on-going project in the lab. For SKN-1 to be activated, SKN-1 has to be transported from the cytoplasm to the nucleus, and for inactivation, it is transported back into the cytoplasm. Investigating what mediates this movement encompasses another on-going project. Using a combination of genetics and biochemistry we hope to better understand how lipids and nuclear transporters regulate SKN-1. These findings will provide insight into the possible role of dietary, metabolic and cellular regulators of stress resistance, longevity and age-associated diseases.
| Lab Member (graduating class) |
Current Position | |
| 2015 - 2017 | Hannah Lombardo ('17) | Research Technician at Dana-Farber Cancer Institute |
| 2015 - 2017 | Jacquelyn Durkan ('17) | Quality Control Associate at Finch Therapeutics |
| 2018 - present | Allison Carroll ('19) | Emmanuel undergraduate |
| 2018 - present | Katherine Gilmore ('19) | Emmanuel undergraduate |
