Associate Dean of Natural Sciences; Professor of Chemistry, Department of Chemistry & Physics
Office: Wilkens Science Center, Room 309-C
Office hours: Tuesday and Thursday, 3:30 p.m.- 5:30 p.m.;and by appointment
Ph.D., M.A., Clark University; M.S., B.S., Pedagogical University, Moscow
- Member of American Chemistry Society
- Member of Molecular Modeling Society
- Member of the Council on Undergraduate Research (CUR), COF liaison officer
- S. Bell "Forensic Chemistry", chapters 6-9, 1st ed., INSB131478354, Prentice Hall, 2006.
- Journal of Chemical Education, 2009 - present
Courses I Teach
- CHEM 1102 - Principles of Chemistry II
- CHEM 1103 - Chemical Perspectives
- CHEM 1107 - Forensic Chemistry
- CHEM 3105 - Physical Chemistry I
- CHEM 3106 - Physical Chemistry II
- CHEM 3121 - Introduction to Molecular Modeling
- CHEM 3116 - Introduction to Research Methods
- CHEM 3211 - Experiential Internship in Natural Sciences
- CHEM 4160 - Senior Seminar in Chemistry
- CHEM 4194/4195 - Research Internship in Natural Sciences
- Workshops for high school science teachers: "Forensic and Environmental Chemistry"
Publications & Presentations
The Extracellular Matrix: an Overview
Chapter in the Research Volume: "The Extracellular Matrix: An Overview", Springer, ISBN 978-3-642-16555-9, 2011 This chapter reviews structural and catalytic properties as well as the roles in biology of these amine oxidases and presents a computer-generated predicted 3D protein structure of LOX.
(* - denotes undergraduate student)
- M. Lynch* and F. Ryvkin "Investigation into Structural Changes of the Copper Binding Site in Lysyl Oxidase upon Substrate and Inhibitor Docking", ISRN Inorganic Chemistry, 2013, Article ID 971764.
- Kagan, H.M and Ryvkin, F. "Lysyl oxidase and Lysyl Oxidase-Like Enzymes", Chapter-review in research volume by invitation: "The Extracellular Matrix: an Overview", Springer press, Mecham, R.P, ed., ISBN 978-3-642-16554-2, 2011.
- F. Ryvkin and F. Greenaway "Modeling Cu(II) binding to peptides using the Extensible Systematic Force Field,", Bioinorganic Chemistry and applications 2010, ID724210, p. 1- 9.
- M. Brockman, A. Schneidewind, M. Lahaie, A. Schmidt*, T. Miura, I. DeSouza, F. Ryvkin, C. Derdeyn, S. Allen, E. Hunter, J. Mulenga, P. Goepfert, B. Walker, and T. Allen, "Escape and Compensation from Early HLA-B57-Mediated Cytotoxic T-Lymphocyte Pressure on Human Immunodeficiency Virus Type 1 Gag Alter Capsid Interactions with Cyclophilin A", Journal of Virology, 2007, v.. 81, #22, p.12608-12618.
- F. Ryvkin and F. T. Greenaway "A peptide Model of the Copper-binding Region of Lysyl Oxidase", Journal of Bioinorganic Chemistry, 98, (2004), pp.1427-1435.
(* - denotes undergraduate student)
- L. Booysen*, C. Messier*, F. Ryvkin, "In silico studies of the lysyl oxidase and lysyl oxidase like-proteins" ACS National Meeting, Washington, DC, August, 2017, poster presentation
- M. Zinter*, C. O'Sullivan*, A.Roy *, F. Ryvkin 'Investigation into the Role of the Copper Cofactor in Lysyl Oxidase, NCUR Conference, University of North Carolina, Asheville, April 2016.
- F. Ryvkin "Designing an introductory molecular modeling course for undergraduate students" -presiding at the Chemistry Education session and presenting, 251st ACS National Meeting, San-Diego, March 2016.
- E. Ste. Marie*, C. Gomes*, C. Palmer*, M. Zinter*, F. Ryvkin "Chemical modifications of the catalytically important residues of enzyme lysyl oxidase ", 249th ACS National Meeting, Denver, March 2015
- Y. Lin, G. Chen*, F. Ryvkin "Molecular modeling of the binding interaction of RGD-functionalized poly(ethylene glycol) hydrogels with lipid bilayer surface", 249th ACS National Meeting, Denver, March 2015
- F. Ryvkin and A. Schmidt "Characterization of lysyl oxidase protein interaction networks using molecular modeling approach", Gordon Research Conference "Regulated proteolysis of cell surface proteins", Ventura, CA, March, 2014.
- C. Gomes*, E. Ste. Marie*, M, Lynch*, F. Ryvkin "Optimization of the initial step of the purification of lysyl oxidase", 245th ACS National Meeting, New Orleans, April 2012
- L. Gagnon* and F. Ryvkin " Size-controlled synthesis of quantum dots for biological and chemical detection" , 245th ACS National Meeting, New Orleans, April 2012
- F. Ryvkin, M. Lynch* and H. Banh* "Effects of copper deletion on the enzymatic activity of lysyl oxidase: molecular modeling approach and structural predictions", Gordon Research Conference "Metals in Medicine", June, 2012
- M. Lynch*, H. Banh*, F. Ryvkin "Elucidating the role of copper within lysyl oxidase via chelation experiments" Sigma Xi Research Society International Meeting, Raleigh, NC, November 2011, Excellence of presentation certificate for Michael Lynch.
- T. Rietz*, M. Lynch*, D. Turman*, F. Ryvkin "Molecular modeling of lysyl oxidase interactions with its substrates and inhibitors", 241th ACS National Meeting, Anaheim, March 2011.
A. Clark*, S. Nugent*, V. Nguyen*, F. Ryvkin "Investigation into the role of copper in catalytic mechanism of lysyl oxidase", Washington DC "Posters on the Hill" April, 2010.
- V. Nguyen*, A. Clark*, F. Ryvkin "Effects of the tryptophan residues modifications on the structure and activity of copper-containing enzyme lysyl oxidase", 239th ACS National Meeting, San Francisco, March 2010.
- F. Ryvkin and A. Harbottle* "Forensic drug testing: false identity", invited presentation at 239th ACS National Meeting, San-Francisco, March 2010.
- J. Barnes*, E. Camire*, H. Kagan, H. Lucero, F. Ryvkin, Purification and characterization of lysyl oxidase from pig aorta", 237th ACS National Meeting, INDOR 1232228, Salt Lake City, March 2009.
- L. Brace*, F. Perler, F. Ryvkin "Molecular modeling of the dra snf2 intein for the investigation of the atypical splicing mechanism", 237th ACS National Meeting, Salt Lake City, March 2009.
- F. Ryvkin "Investigation into the role of copper in lysyl oxidase: evidence and model", Gordon Research Conference "Metals in Medicine", June, 2008.
- F. Ryvkin and R. Hunt*, "Camera, light, action: The effective use of films as a teaching tool in forensic science course", invited presentation at 234th ACS National Meeting, Boston, MA, August, 2007, sponsored by Center for Workshops in the Chemical Sciences (NSF). Professional Reviewing
- Reviewer for the Journal of Chemical Education 2010 – present
Grants & Recognition
- Marion and Jasper Whiting Foundation grant, 2014
- Northeastern ACS section grant-in aid travel award to present at National ACS meeting, Spring 2013
- Sigma Xi Research Society grant-in-aid, Fall 2012
- NSF multiple users’ instrumentation grant for the acquisition of X-band EPR spectrometer with low temperature accessories, Fall 2011
- Northeastern ACS section grant-in aid travel award to present at National ACS meeting, Spring 2010
- Faculty Excellence Award, Emmanuel College, 2007
My field of research interest is a fast developing filed of bioinorganic chemistry, an interface of chemical, physical and computational methods applied to structural and functional properties of metal-containing proteins and enzymes. My work for past few years focused primarily on characterization of copper-containing enzyme lysyl oxidase and on understanding a role that copper ion may have in this system. Little is known about the role of copper in the catalytic mechanism of this enzyme, and it has been debated whether its function is catalytic or structural. There is essentially no information available concerning specific amino acids residues which might function in lysyl oxidase catalysis and inhibition. We are currently rigorously characterize the copper- binding site of this intruguing enzyme by kinetic, spectroscopic, and structural methods in order to elucidate its properties. I believe that the ability to work individually with students on a research project is an invaluable part of undergraduate science education, and I am especially proud to have all this accomplished when working with Emmanuel College students who have undying enthusiasm and dedication for these challenging projects and always go far beyond what you might expect from undergraduate students.