Our Faculty

Courses I Teach

• PHYS 2201 General Physics I
• PHYS 2202 General Physics II
• PHYS 1121/1122 Energy and the Environment
• PHYS 2410 Sustainability Science
• CHEM 1110 Introduction to Physical Science
• CHEM 2111 Biochemistry I
• CHEM 3121 Introduction to Molecular Modeling
• CHEM 4160 Senior Seminar in Chemistry
• CHEM 4194-4195 Research Internships in the Natural Sciences I & II
• FYS1101-65 The Heat is On: the Science and Future of Global Climate Change

• "Salt concentration modulates the DNA target search strategy of NdeI," R.M. Ferreira, A.D. Ware, E.K. Matozel, A.C. Price, Biochemical and Biophysical Research Communications (2020).
• "Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage," E.K. Matozel, N. Dale, A.C. Price, J. Vis. Exp. 159: e61236, doi:10.3791/61236 (2020).
• "The role of noncognate sequences in the 1D search mechanism of EcoRI", S. Piatt, J.J. Loparo, A.C. Price, Biophysical Journal 116: 2367-2377 (2019).
• "Analyzing dwell times with the Generalized Method of Moments," S. Piatt, and A.C. Price, PLOS ONE 14.1: e0197726 (2018).
• “A single molecule assay for measuring site-specific DNA cleavage,” S. Gambino, B. Mousley, L. Cathcart, J. Winship, J.J. Loparo, A.C. Price, Analytical Biochemistry 495: 3-5 (2016).
• “DNA motion capture reveals the Mechanical Properties of DNA at the Mesoscale,” A.C. Price, K.R. Pilkiewicz, T.G.W. Graham, D. Song, J.D. Eaves, J.J. Loparo Biophysical Journal 108(10): 2532-2540 (2015).
• “Tethered particle motion with single DNA molecules,” D. Song, B. Mousley, S. Gambino, E. Helou, J. Loparo, A.C. Price, American Journal of Physics 83(5): 418-426 (2015). 
• "A single molecule DNA flow stretching microscope for undergraduates," K. Williams, B. Grafe, K. Burke, N. Tanner, A. M. van Oijen, J. Loparo and  A.C. Price, American Journal of Physics 79(11): 1112-1120 (2011). 
• “Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase,” Raymer B, Kavana M, Price A, Wang B, Corcoran L, Kulathila R, Groarke J, Mann T Bioorg Med Chem Lett.May 15;19(10):2804-7. (2009).
• “The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9,” R. Kulathila, B. Vash, D. Sage, S. Cornell-Kennon, K. Wright, J. KoehnT. Stams, K. Clark, A. Price, Acta Cryst. D65, 58-66 (2009).
• "Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison," He X, van Waardenburg RC, Babaoglu K, Price AC, Nitiss KC, Nitiss JL, Bjornsti MA, White SW, J Mol Biol. 372, 1070 (2007).
• “Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli,” Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS., J Med Chem. 49, 159 (2006).
• “Cofactor-induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG,” A.C. Price, Y.M. Zhang, C.O. Rock and S.W. White, Structure 12, 417 (2004).
• “The 1.3 Angstrom Resolution Crystal Structure of beta-Ketoacyl-[Acyl Carrier Protein] Synthase II from Streptococcus pneumoniae,” A.C. Price, C.O. Rock and S.W. White, Journal of Bacteriology 185, 4136 (2003).
• “A Missense Mutation in the fabB (beta-Ketoacyl-[Acyl Carrier Protein] Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli,” S. Jackowsi, Y.M. Zhang, A.C. Price, S.W. White and C.O. Rock, Antimicrobial Agents and Chemotherapy 46, 1246 (2002).
• “The Structure of beta-Ketoacyl-[Acyl Carrier Protein] Reductase from Escherichia coli: Negative Cooperativity and its Structural Basis,” A.C. Price, Y.M. Zhang, C.O. Rock and S.W. White, Biochemistry 40, 12772 (2001).
• “Inhibition of beta-Ketoacyl-[Acyl Carrier Protein] Synthase by Thiolactomycin and Cerulenin: Structure and Mechanism,” A.C. Price, K.H. Choi, R.J. Heath, Z. Li, S.W. White and C.O. Rock, Journal of Biological Chemistry 276, 6551 (2001).
• “Identification and Analysis of the Acyl Carrier Protein (ACP) Docking Site in beta-Ketoacyl-Acyl Carrier Protein Synthase III,” Y.M. Zhang, M.S. Rao, R.J. Heath, A.C. Price, A.J. Olsen, C.O.Rock and S.W. White, Journal of Biological Chemistry 276, 8231 (2001).
• “Coherent Soft X-Ray Dynamic Light Scattering from Smectic-A Films,” A.C. Price, L.B. Sorensen, S.D. Kevan, J. Toner, A. Poniewierski and R. Holyst, Physical Review Letters 82, 755 (1999).
•  “Dynamic Critical Behavior of the Landau-Peierls Fluctuations: Scaling form of the Dynamic Density Autocorrelation Function for Smectic-A Films,” A. Poniewierski, R. Holyst, A.C. Price and L.B. Sorensen, Physical Review E 59, 3048 (1999).
• “The Dynamic Correlation Functions for Finite and Infinite Smectic-A Systems: Theory and Experiment,” A. Poniewierski, R. Holyst, A.C. Price, L.B. Sorensen, S.D. Kevan and J. Toner, Physical Review E 58, 2027 (1998).

I use quantitative science to understand the molecular basis of life. My students and I have developed methods to observe interactions between individual molecules of DNA and proteins. Our data has helped us understand how DNA binding proteins search the genome for their specific binding sites. This work has contributed to our fundamental understanding of genetic regulation in cells as well as to evolving biotechnology such as gene editing. We are also developing and applying methods in data science, such as computer vision and numerical simulations, to complex biomolecular processes.