Our Faculty

R. Bryan Sears

Assistant Professor of Chemistry, Department of Chemistry & Physics


Contact Information

617-735-9890


Office Hours

Office: Administration Building, Room 420D

Office hours: Monday, 3:00 p.m.-5:00 p.m.; Thursday 2:00 p.m.-4:00 p.m., by appointment also

Education

Ph.D., The Ohio State University, B.S. in Chemistry, Georgia Southern University


slideshowWhat I'm Working On


Courses I Teach

  • CHEM 1101 Principles of Chemistry I
  • CHEM 1102 Principles of Chemistry II
  • CHEM 1103 General Perspectives
  • CHEM 2115 Inorganic Chemistry
  • CHEM 4160 Senior Seminar

Publications + Presentations

"Advancing photodynamic therapy with biochemically tuned liposomal nanotechnologies"

Book Chapter: Huang, Huang-Chiao; Mallidi, Srivalleesha; Obaid, Girgis; Sears, R. Bryan; Tangutoori, Shifalika; Hasan, Tayyaba. 1st ed. Applications of Nanoscience in Photomedicine. Elsevier. August 2014.


"Enhancing Photodynamic Treatment of Cancer with Mechanism-based Combination Strategies"

Book Chapter: Zheng, Lei; Sears, R. Bryan; Kiamani, Stanley; Massodi, Iqbal; Hasan, Tayyaba. Handbook of Photomedicine. 1st ed. Taylor and Francis, London. 2013.  353-367.


Peer-Reviewed Articles:

  • Spring, Bryan Q.;Abu-Yousif, Adnan O.; Palanisami, Akilan; Rizvi, Imran; Zheng, Xiang; Anbil, Sriram; Sears, R. Bryan; Mensah, Lawrence; Goldschmidt, Ruth; Erdem, S. Sibel; Oliva, Esther;  Hasan, Tayyaba. "Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates" PNAS. 2014. doi:10.1073/ pnas.1319493111
  • Spring, Bryan Q.; Palanisami, Akilan; Zheng, Lei; Blatt, Amy E.; Sears, R. Bryan; Hasan, Tayyaba. Efficient measurement of total tumor microvascularity ex vivo using a mathematical model to optimize volume sub-sampling. Journal of Biomedical Optics. 2013 18(9).
  • Sears, R. Bryan; Joyce, Lauren; Ojaimi, Maya; Gallucci, Judith; Thummel, Randolph; Turro, Claudia. "Photoinduced Ligand Exchange and DNA Binding of [Ru(phpy)(phen)(CH3CN)2]+ in the PDT Window". J. Inorganic Biochem. 2013. 121 (2013) 77-87.
  • Plamer, Alycia; Pena, Bruno; Sears, R. Bryan; Chen, Olivia; Thummel, Randolph; Dunbar, Kim; Turro, Claudia. "Cytotoxicity of Cylcometallated Ruthenium Complex: The Role of Ligand Exchange on the Activity. RSC Phil Trans. A. 2013 371(1995), 20120135.
  • Sears, R. Bryan; Joyce, Lauren; Turro, Claudia. Electronic Tuning of t2g Orbitals by 8-quinolate Ligands in Ruthenium Complexes. Photochemistry and Photobiology. 2010, 86, 1230-1236.
  • Hand, James K.; Stewart, Amanda L.; Sears, R. Bryan; McCall, Trianna R.; Davis-McGibony, Catherine M. A novel synthesis of p-nitrobenzylphosphonic acid and its action on alkaline phosphatase.   Letters in Organic Chemistry.  2008, 5(7), 563-565.
  • Hand, J. Kevin; Sears, R. Bryan; Davis-McGibony, C. Michele. Phosphonylation of an Alkyl Bromide. Synthetic Pages, 2005, 226
  • Sears, R. Bryan; Hill, April J.; Davis-McGibony, C. Michele. Location and distribution of adenochrome in the common brown octopus. Journal of Undergraduate Chemistry Research.  2005, 4(2), 63-66.
  • Sears, R. Bryan; Carpenter, Russell A.; Whitlock, Christine R.   A general synthesis of tris-indole derivatives as potential iron chelators. Molecules. 2005, 10(2), 488-491.

Book Chapters:

  • Huang, Huang-Chiao; Mallidi, Srivalleesha; Obaid, Girgis; Sears, R. Bryan; Tangutoori, Shifalika; Hasan, Tayyaba. Advancing photodynamic therapy with biochemically tuned liposomal nanotechnologies. 1st ed. Applications of Nanoscience in Photomedicine. Elsevier. August 2014.
  • Zheng, Lei; Sears, R. Bryan; Kiamani, Stanley; Massodi, Iqbal; Hasan, Tayyaba. Enhancing Photodynamic Treatment of Cancer with Mechanism-based Combination Strategies.  Handbook of Photomedicine. 1st ed. Taylor and Francis, London. 2013.  353-367.

Patents:

  • Turro, Claudia; Martin, Edward; Povoski, Stephen; Subrmaminiam, Vish; Heremans, Joseph; Sun, Duxin; Sears, R. Bryan. Intra-Operative Probe for Real-time Detection of Occult Tissue. 2009.  U.S. Patent App. 2009/0234225 A.

Presentations (from 25 abstracts and seminars):

  • Sears, R. Bryan. "Early integration of scientific critique and writing in undergraduate inorganic chemistry curriculum." Abstracts of Papers, 247th ACS National Meeting, Dallas, TX, United States, March 19, 2014.
  • Sears, R. Bryan. "Development of Novel Therapeutics, Combinations and Formulations of Photodynamic Therapy Agents for the Treatment of Cancers." Faculty Research Seminar, Emmanuel College. February 28, 2014.
  • Sears, R. Bryan; Turro, Claudia; Hasan, Tayyaba. "Development of Novel Therapeutics, Combinations and Formulations of Photodynamic Therapy Agents for the Treatment of Cancers." Abstracts of Papers, 244th ACS National Meeting, Philadelphia, PA, United States, August 19-23, 2012.
  • Sears, R. Bryan.  "Photomedicine:  Introduction to the Basics of Photochemistry and Spectroscopy".  HST-MIT Biomedical Optics School, Wellman Center for Photomedicine, Boston, MA, United States, July 30, 2012.
  • Sears, R. Bryan; Zheng, Lei; Hasan, Tayyaba. "Using Nanotechnology for Multi-Compartmentalized Delivery of Photosensitizer and c-Met Inhibitor to Enhance Treatment of Cancer." Abstracts, 36th Annual Meeting of the American Society for Photobiology, Montreal, QC, Canada, June 24-28. 2012.
  • Sears, R. Bryan "Development of An Intra-Operative Probe for near-IR Detection of Occult Tissue."  Abstracts, 40th Central Regional Meeting of the American Chemical Society, Columbus, OH, United States, June 10-14. 2008.
  •  Sears, R. Bryan; Hand, J. Kevin; Davis-McGibony, C. Michele. "Chelation studies of the marine metabolite Adenochrome." Abstracts of Papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005.
  • Sears, R. Bryan; Whitlock, Christine R.   "A General Synthesis of Tris-Indole Amines as Potential Iron Chelators".   Abstracts, 56th Southeast Regional Meeting of the American Chemical Society, Research             Triangle Park, NC, United States, November 10-13, 2004.
  • Sears, R. Bryan; Stewart, Amanda L.; Davis, C. Michele. "Investigations of Adenochrome: A Potential Iron Chelation Therapy Drug." Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, March 27-30, 2004.
  • Sears, R. Bryan; Rivera-Hainaj, Rosa. "Unveiling molecular binding interactions of SH3 homologies with model proline rich peptides by FT-IR spectroscopy." Abstracts of Papers, 227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1, 2004.
  • Sears, R. Bryan; Davis, C. Michele. "Adenochrome: Location and distribution in an octopus." Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003.

Grants + Recognition

Funding Support:

  • Emmanuel College Teaching with Technology, 2013
  • Herchell Smith-Harvard Undergraduate Science Research Grant, 2012 - 2013
  • Interdisciplinary Mechanical Engineering Research Grant, 2008 - 2009

Awards:

  • MGH Office of Research & Career Development Prestige Award, 2012
  • American Society for Photobiology Urbach Award, 2012
  • AAAS Award for Outstanding Achievement, 2005
  • Valedictorian Graduating Chemistry Major, 2005
  • NSF-REU Fellow, James Madison University, 2004

Editorial Activities:
Ad hoc Reviewer

  • Photochemistry and Photobiology
  • Nature Protocols
  • Reviews in Medicinal Chemistry
  • JACS Communication
  • Biotechnology Progress
  • J. Inorganic Biochemistry

Research Focus

Combining inorganic synthesis, nanotechnology, formulation science and spectroscopy, my research group incorporates a multidisciplinary team to synthesize novel inorganic complexes, which undergo a photoinduced ligand exchange upon irradiation for use in Photodynamic Therapy in the treatment of cancer. Currently, my research group can be divided in three teams: 1) an inorganic core lab which focuses on synthesis and photophysical characterization of new metal coordination complexes, 2) a spectroscopy lab that investigates the excited state dynamics of potential photochemotherapy agents and photophysics in biological milieu and 3) a pharmacology team that formulates these complexes into nano-sized "pills" which contain a photo-triggered agent.  In order to achieve these research goals, undergraduate researchers in my lab work on a personalized research project but heavily collaborate with one another to achieve the overall research goal; a photo-deliverable photodynamic therapy agent.