Ph.D., Analytical Chemistry, Vanderbilt University; B.A., Chemistry, Hanover College
Chemistry is everywhere! Chemistry and chemicals make the paper (or screen) this is printed on brilliant white and the ink (or type) a deep black. It makes combustion engines run and chemical reactions are required in each step of our very complex digestive process. These molecular interactions have continually amazed me from the first time that I really learned about chemistry in high school. I believe that these exciting notions and my own excitement can get students in the door and on board with science. Understanding the principles behind everyday life is important, though there are other crucial skills that can be learned through chemistry. The most important skills that I have developed in my years as a chemistry student, laboratory researcher, and chemistry teacher are the abilities to think critically about all areas of science and to approach problem solving effectively. These skills have served me well in many aspects of life, from advanced laboratory research to understanding world issues. My philosophy is that chemists and all liberal arts students should be educated using real world examples that place an emphasis on critical thinking and problem-solving. I believe that an undergraduate liberal arts education focusing in chemistry offers an ideal medium for the development of these skills and that critical thinking, not fact memorization, should be the focus of science education.
What I'm Working On
What I Love About Emmanuel:
I love that Emmanuel College embraces the liberal arts. Chemistry majors put science in perspective through social analysis or moral reasoning while students focused on the humanities learn the importance of science in daily life. The same is true for faculty members that work together to provide a learning environment without boundaries.
Courses I Teach
- CHEM 1101 Principles of Chemistry I
- CHEM 1102 Principles of Chemistry II
- CHEM 1103 Chemistry Perspectives
- CHEM 2104 Analytical Chemistry
- CHEM 2114 Chemistry of Fire and Explosives
- CHEM 3108 Instrumental Methods of Analysis
- CHEM 4160 Senior Seminar
Publications + Presentations
- Carter, M.D.; Pierce, S.S.; Dukes, A.D., III; Brown, R.H.; Crow, B.S.; Shaner, R.L.; Heidari, L.; Isenberg, S.L.; Perez, J.W.; Graham, L.A.; Thomas, J.D.; Johnson, R.C.; Gerdon, A.E. "Supplemental Learning in the Laboratory: An Innovative Approach for Evaluating Knowledge and Method Transfer" J. Chem. Ed. 2017, 94, 1094-1097.
- Baillargeon, K.R.; Meserve, K.; Faulkner, S.; Watson, S.; Butts, H.; Deighan, P.; Gerdon, A.E. "Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis" Chem. Commun. 2017, 53, 1092-1095.
- Connelly, C.; Cicuto, T.; Leavitt, J.; Petty, A.; Litman, A.; Margolis, H.C.; Gerdon, A.E. "Dynamic interactions of amelogenin with hydroxyapatite surfaces are dependent on protein phosphorylation and solution pH" Coll. Surf. B 2016, 148, 377-384.
- Conklin, G.; Ngourn, S.C.; Gerdon, A.E. "Quartz crystal microbalance with microfluidic multi-stream solution control for mineralization kinetic analysis" Sens. Actuators B 2015, 214, 174-180.
- Vasconcellos, K.B.; McHugh, S.M.; Dapsis, K.J.; Petty, A.R.; Gerdon, A.E. "Biomimetic nanoparticles with polynucleotide and PEG mix-monolayers enhance calcium phosphate mineralization" J. Nanoparticle Res. 2013, 15, 1942.
- Ngourn, S.C.; Butts, H.A.; Petty, A.R.; Anderson, J.E.; Gerdon, A.E. "Quartz Crystal Microbalance Analysis of DNA-templated Calcium Phosphate Mineralization" Langmuir 2012, 28, 12151-12158.
- Meserve, K.; Gerdon, A.E. "Precipitation SELEX: selection and study of DNA aptamers that template calcium phosphate mineralization" 20th Annual Northeast Student Chemistry Research Conference, Boston, MA, 2018.
- Conte, N.; Fullerton, K.; Percuoco, M.; Gerdon, A.E. "Determination of water hardness and heavy metal concentrations in Boston water samples" Abstracts of Papers, 12th Annual Muddy River Symposium, Colleges of the Fenway, Boston, MA 2018.
- Gerdon, A.E. "Evidence for DNA as a biomimetic template in calcium phosphate mineralization" Abstracts of Papers, 255th National Meeting of the American Chemical Society, New Orleans, LA, 2018; COLL presentations. 4.
- Meserve, K.; Gerdon, A.E. "Precipitation SELEX: selection and study of DNA aptamers that template calcium phosphate mineralization" Abstracts of Papers, 255th National Meeting of the American Chemical Society, New Orleans, LA, 2018; CHED poster.
- Miech, J.; Gerdon, A.E. "Microfluidic platforms for analyzing the effect of biomimetic templates on calcium phosphate mineralization" Abstracts of Papers, 255th National Meeting of the American Chemical Society, New Orleans, LA, 2018; ANYL poster.
- Tzepos, R.G.; Gerdon, A.E. "Cobalt protoporphyrin IX nanoparticles provide signal amplification in anodic string voltammetry for protein biomarker detection" Abstracts of Papers, 255th National Meeting of the American Chemical Society, New Orleans, LA, 2018; ANYL poster.
Grants + Recognition
- Gerdon, A.E. "RUI: Selection and Assessment of Biomimetic Templates for Mineralization", National Science Foundation, Research at Undergraduate Institutions, July 2013 - June 2016, Awarded: $240,086.
- Gerdon, A.E. Instrumentation Grant, 2012 Pittsburgh Conference Memorial National College Grants Program, 2012, Awarded: $3,461.
- Gerdon, A.E., Yamakoshi, Y., Fratzl, P., Beniash, E. (co‐investigators); Margolis, H.C. (principle investigator); "Matrix Protein Regulation of Enamel Mineral Formation", National Institute of Health, Recovery Act Administrative Supplement, August 2009 - July 2010, Awarded: $139,021 (total); $14,460 (Emmanuel College).
As scientists, we feel motivated to better understand the complexities around us and make innovative changes in our ever-evolving world. The research done by Dr. Gerdon's undergraduate students at Emmanuel College motivates and educates students in chemistry using a simple philosophy. First and foremost, our research aims to inspire students in chemical research by giving them hands-on instruction in a professional laboratory setting. Experimentation in novel areas of chemistry such as nanotechnology encourages students to explore their curiosities and gain experience in the field of research. Second to education, our researchers complete scientifically relevant experiments in three main fields of study: biomineralization, analytical biochemistry, and nanotechnology.
Biomineralization refers to the process of mineralization taking place within nature. A multitude of examples can be found across the animal kingdom, but the process of biomineralization is still not well understood. Biomineralization can be seen on a macroscopic and microscopic level, whether it be the calcite formed by lobsters or the magnetite mineralized by bacteria. The ability of a living being to form mineral from its environment or its own body is often advantageous to its survival. Our research focuses on the biomineralization pathway of hydroxyapatite. This highly structured, crystalline calcium phosphate mineral is the main component of teeth and bones in mammals. Hydroxyapatite is largely responsible for the strength of teeth, as it's highly ordered crystal lattice structure provides rigidity. In our quest to understand how hydroxyapatite is formed, we hope to eventually offer some insight into bone health and regeneration.
Besides directly studying mineral formation, biochemistry and biomimetic processes are used to better understand hydroxyapatite. By making use of the biochemical properties of hydroxyapatite, we can gain insight into its formation and functioning in a physiological setting. We focus our efforts on an extracellular matrix protein called amelogenin. This protein is involved with the formation of enamel and is believed to regulate the growth of hydroxyapatite. The biochemistry between hydroxyapatite and amelogenin enables us to learn more about hydroxyapatite in comparison with other calcium phosphate minerals.
Biomimetics, the imitation or modeling of systems found in nature, can also be used to study the formation and properties of hydroxyapatite. Scientists have benefited greatly from studying the unique skills organisms have developed over years simply by natural selection. By mimicking these skills, we can make use of them to learn more about the world around us. We use two biomimetic models in our research: DNA and nanoparticles. DNA is a molecule made up of nucleic acids that are held together by a negatively charged backbone. This backbone acts as a scaffold for the formation of hydroxyapatite. Similarly, we are using nanoparticles as a way to synthesize hydroxyapatite more efficiently. Nanoparticles are particles with a diameter anywhere between 1 and 100 nanometers. Both of these templates are a part of the larger field of biomimetic technology, which continues to be explored with great enthusiasm in our lab and beyond.
Our researchers gain valuable laboratory skills as they are exposed to a variety of different instrumental techniques. They learn how to conduct research in a professional laboratory setting, while contributing to the scientific community in a meaningful way. We learn to use a variety of instruments and analytical techniques such as microscopy, gel electrophoresis, spectroscopy, and more. Our researchers are even developing their own analytical methods to measure hydroxyapatite mineralization. Each different avenue of experimentation is helping to shed light on the process of biomineralization, in the hopes of contributing to biotechnological solutions to bone regeneration and repair.